Schedule

Note that all times are in UK local time (BST)

Diamond Biological Cryo-imaging User Meeting: eBIC & B24

Session 1:

On demand video link includes Session 1 & 2 recordings.

13:00

Welcome

Martin Walsh

(Diamond)

13:10

eBIC user updates

Kyle Morris

(eBIC Diamond)

13:40

Structural insights into the nuclear import of mammalian proteasomes

David Haselbach

IMP Vienna

14:10

Mechanism of dynein-2 in intraflagellar transport

Katerina Toropova

Birkbeck

14:40

Break

Session 2

On demand video link includes Session 1 & 2 recordings.

15:30

B24 user updates

Chidinma Okolo

(B24 Diamond)

16:00

Integrative imaging of SARS-CoV-2 infection

Luiza Mendonca

Oxford

16:30

User meeting round-table discussion

Chairs: Natasha Lukoyanova (Birkbeck) & Jamie Blaza (York) During the user meeting eBIC representatives will discuss topics raised in the eBIC User Survey.

17:15

Close

19:00

Informal conference dinner

Pizza & beer mixer

CCP-EM Spring Symposium VIII

Nottingham EMCC

Session 1:

On demand video link includes Session 1 & 2 recordings.

9:00

Opening and welcome

Matt Iadanza

What’s new in CCP-EM, eBIC, RFI & EMDB/EMPIAR/CCP-EM

9:30

eBIC

Karen Davies

10:00

RFI

Michael Grange

10:30

EMDB/EMPIAR

Gerard Kleywegt

11:00

Coffee

Session 2:

On demand video link includes Session 1 & 2 recordings.

11:30

RELION 4 and beyond – Structural heterogeneity and algorithmic robustness

Dari Kimanius

MRC-LMB

12:00

Map post-processing with DeepEMhancer

Ruben Sanchez-Garcia

Oxford

12:30

Zernikes3D: Analysis of conformational landscapes from CryoEM data

David Herreros

National Central for Biotechnology, CSIC

12:50

Lunch

Session 3:

14:30

The physical origins of specimen movement in electron cryomicroscopy

Katerina Naydenova

MRC-LMB

15:00

Towards Microsecond Time-Resolved Cryo-Electron Microscopy

Ulrich Lorenz

EPFL

15:30

Structural diversity of GABA(A) receptors

Andrija Sente

MRC – Laboratory of Molecular Biology

15:50

Coffee

Session 4:

16:30

New methods for preparing, imaging and processing cryo-EM samples

Tim Grant

UW-Madison

17:00

Overview of recent developments for tools in Phenix for cryo-EM

Dorothee Liebschner

Berkeley Lab

17:30

Progress and Problems in cryo-EM Validation

Peter Rosenthal

Crick

19:00

Conference dinner

Session 5:

On demand video link includes Session 5 & 6 recordings.

9:00

Cryo-electron tomography and subtomogram averaging for structural determination of membrane coat complexes

Giulia Zanetti

Birkbeck

9:30

Cryo-electron tomography workflows to extract quantitative and geometrical information from variable protein assemblies

Florian Schur

IST-Austria

10:00

Capturing Inhibited Assemblies of the Membrane Attack Complex by CryoEM

Emma Couves

Imperial College, London

10:20

Coffee

Session 6:

On demand video link includes Session 5 & 6 recordings.

11:10

Automated data acquisition for high-resolution tomography and subtomogram averaging

Wim Hagen

EMBL

11:40

Single particle cryoEM pipelines (reasons to be optimistic)

Rebecca Thompson

Leeds

12:10

Using cryo-EM of SARM1 to help design new therapeutics against neurodegenerative disease

Katie Cunnea

Evotec

12:30

Lunch

Session 7:

14:00

How to deal with large and dynamic macromolecular complexes

Holger Stark

MPI Biophysical Chemistry

14:30

Discovery of a druggable pocket and a drug in SARS-CoV-2 spike glycoprotein

Christiane Berger-Schaffitzel

Bristol

15:00

Cryo-EM structures of the deltaretroviral intasome in complex with the host factor Protein Phosphatase 2A subunit B56γ and HIV integrase inhibitors

Goedele Maertens

Imperial

15:30

A conserved mechanism for regulating replisome disassembly revealed by cryo-EM

Tom Deegan

Glasgow

16:00

Meeting close